Regenerative Medicine Applications in Organ Transplantation by Giuseppe Orlando download in ePub, pdf, iPad
Both of these situations are limited to a really few number of recipients, while the majority of them have to face with inadvertent complications of immunosuppression after transplantation. This background needs to be dealt with immediate attention and demands for finding an alternative source of organ transplantation. They also have malignant potential, and also have issues with rejection and ethical concerns. Nevertheless, such constructs receive nutrients and oxygen by diffusion from adjacent tissues, because they lack vascular supply. Consequentially, exogenous regenerative strategies, especially cell replacement therapy, have emerged and attracted increasingly more attention in the field of cardiac tissue regeneration.
Still, bioengineering of cardiac, hepatic, renal, pancreatic, and intestinal organ-like constructs is not practically possible. Human embryonic stem cells in regenerative medicine. Given the so far unsolved obstacle, all hope-raising procedures to possibly tackle this long-lasting problem can draw attentions. Originally described by Vacanti et al. Stem cells taken from the patient's hip were treated with growth factors and incubated on a plastic replica of his natural trachea.
The first category includes transplantation of human cells from a donor to a patient. Porous biomaterials, such as alginate or poly-glycolide-co-lactide like polymers, have also been tested as cell scaffolds with human embryonic stem cell-derived cardiomyocytes.
Tissue engineering in regenerative medicine. The main restriction of this modality is, however, organ shortage. Important cross references were also studied and only relevant information was compiled. Limited supply of organs is causing serious crime of organ trafficking.
Still, and maybe in near future, human organs will be the only source for transplantation. This approach is based on the concept that a missing organ can be generated from exogenous cells when functionally normal pluripotent cells chimerize a cloned dysorganogenetic embryo. This approach has been extended to treat patients with tracheal cancer. However, it did not regenerate the alignment of the circular and longitudinal smooth muscle that is crucial for generating appropriate force and motility to facilitate nutrient absorption. Nevertheless, we have not yet found ways to overcome the complex issue of the shortage of organs for transplantation.
Utilizing this concept successful generation of secretory mammary glands was achieved by transplanting single stem cells isolated from adult mouse mammary glands into the fat-pad in mice. Vascularization Notably, all bioengineered organs that to date have been implanted successfully have been hollow organs in which reconnection to the systemic vascular system is not necessary. However, this status is neither immediate, nor stable.
Regardless of whether regenerative organ therapy succeeds, we believe it may generate new knowledge and new visions about how organs may be replaced in the future. Regenerative medicine and the developing world.
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